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Related Party Transactions - Overview of Related Parties (Details) - USD ($)
$ / shares in Units, $ in Millions
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Jan. 21, 2018
Dec. 31, 2017
Related Party Transactions        
Ownership percentage     48.40%  
Number of Warrants 23,351,052     43,757,379
Exercise price of warrants $ 0.03     $ 0.24
Common stock issued in lieu of board fees 13,349 12,917    
Maximum        
Related Party Transactions        
Proceeds from issuance of common stock in lieu of director board and committee fees $ 0.1 $ 0.1    
Common Stock | Board of Director        
Related Party Transactions        
Ownership percentage 18.00%      
Pillar Investment Entities | Common Stock        
Related Party Transactions        
Ownership percentage 12.00%      
Besancon        
Related Party Transactions        
Number of Warrants 1,200,000      
Exercise price of warrants $ 0.47      
Baker Bros. Advisors LP        
Related Party Transactions        
Number of warrants exercised 20,316,327      
Proceeds from exercise of warrants $ 9.5      
Exercise price of warrants $ 0.47      
Baker Bros. Advisors LP | Pre-funded Warrants        
Related Party Transactions        
Number of Warrants 22,151,052      
Exercise price of warrants $ 0.01