Alliance Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2018	Mar. 31, 2017
Alliance Revenue
Alliance revenue	$ 255	$ 378
Deferred revenue recognized during the period	200	300
Gsk Collaboration
Alliance Revenue
Alliance revenue	142	371
Vivelix Collaboration
Alliance Revenue
Alliance revenue	56
Other
Alliance Revenue
Alliance revenue	$ 57	7
Additional Research Services
Alliance Revenue
Deferred revenue recognized during the period		$ 100

Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 32
-Paragraph 2A
-URI http://asc.fasb.org/extlink&oid=82859839&loc=SL82860478-203043

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=82913847&loc=SL49130539-203045

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=82913847&loc=SL49130543-203045

Reference 4: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=82913847&loc=SL49130545-203045

Name:	us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration