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Related Party Transactions - Overview of Related Parties (Details) - USD ($)
$ / shares in Units, $ in Millions
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Jan. 21, 2018
Related Party Transactions        
Ownership percentage       48.40%
Number of Warrants 43,757,379 51,709,460    
Exercise price of warrants $ 0.24 $ 0.31    
Common stock issued in lieu of board fees 62,939 101,239 40,934  
Proceeds from issuance of common stock in lieu of director board and committee fees $ 0.1 $ 0.2 $ 0.1  
Common Stock | Board of Director        
Related Party Transactions        
Ownership percentage 9.40%      
Pillar I        
Related Party Transactions        
Number of warrants exercised   1,370,000    
Proceeds from exercise of warrants   $ 2.0    
Pillar II        
Related Party Transactions        
Number of warrants exercised 5,034,061   232,759  
Proceeds from exercise of warrants $ 3.5   $ 0.2  
Pillar III        
Related Party Transactions        
Number of warrants exercised     2,600,000  
Proceeds from exercise of warrants     $ 1.2  
Pillar Investment Entities | Common Stock        
Related Party Transactions        
Ownership percentage 13.10%      
Besancon        
Related Party Transactions        
Number of warrants exercised 2,918,020      
Proceeds from exercise of warrants $ 1.9      
Number of Warrants 1,200,000      
Exercise price of warrants $ 0.47      
Baker Bros. Advisors LP        
Related Party Transactions        
Number of Warrants 20,316,327      
Exercise price of warrants $ 0.47      
Baker Bros. Advisors LP | Pre-funded Warrants        
Related Party Transactions        
Number of Warrants 22,151,052      
Exercise price of warrants $ 0.01