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CONDENSED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Cash Flows from Operating Activities:    
Net loss $ (51,058) $ (39,211)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation 9,165 5,127
Issuance of common stock for services rendered 119 129
Accretion of discounts and premiums on investments 94 466
Depreciation and amortization expense 559 484
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (1,639) (48)
Accounts payable, accrued expenses, and other liabilities (393) 937
Deferred revenue (606) (833)
Net cash used in operating activities (43,759) (32,949)
Cash Flows from Investing Activities:    
Purchases of available-for-sale securities   (2,946)
Proceeds from maturity of available-for-sale securities 26,870 29,946
Proceeds from sale of available-for-sale securities   1,974
Purchases of property and equipment (100) (369)
Net cash provided by investing activities 26,770 28,605
Cash Flows from Financing Activities:    
Proceeds from exercise of common stock warrants and options and employee stock purchases 488 111
Payments on note payable (216) (193)
Payments on capital lease (9) (6)
Net cash provided by (used in) financing activities 263 (88)
Net decrease in cash and cash equivalents (16,726) (4,432)
Cash and cash equivalents, beginning of period 80,667 26,586
Cash and cash equivalents, end of period $ 63,941 $ 22,154