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Stockholders' Equity - Stock Options (Details) - shares
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Class of Stock    
Common stock, shares reserved for future issuance 76,137,792  
Maximum number of additional common shares 6,946,975  
Minimum option exercise price as a percentage of market value of common stock 100.00%  
Common stock options outstanding 18,002,000 16,261,000
Options outstanding under earlier plans 4,616,437  
Grant of inducement stock option 1,150,000  
Inducement grants outstanding shares 3,150,000  
2013 Stock Incentive Plan    
Class of Stock    
Stock options, expiration period 10 years  
Common stock, shares reserved for future issuance 15,224,460  
Maximum number of shares that may be granted to any one individual in single year 1,500,000  
Common stock options outstanding 10,235,083  
Common shares available for grant 6,275,852  
Minimum | 2013 Stock Incentive Plan    
Class of Stock    
Stock options, vesting period 3 years  
Maximum | 2013 Stock Incentive Plan    
Class of Stock    
Stock options, vesting period 4 years