XML 63 R47.htm IDEA: XBRL DOCUMENT v3.6.0.2
Collaboration and License Agreements (Details)
$ in Thousands
1 Months Ended 12 Months Ended
Nov. 30, 2016
USD ($)
Nov. 30, 2015
USD ($)
item
person
May 31, 2014
USD ($)
Apr. 30, 2014
USD ($)
Dec. 31, 2016
USD ($)
item
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Remaining performance obligation         $ 0    
Alliance revenue         16,199 $ 249 $ 73
Deferred revenue, current portion         1,111 1,111  
Deferred Revenue, Noncurrent         152 1,262  
Expenses         54,956 49,095 38,825
Abbott Molecular              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Paid or expects to pay for external development expenses     $ 6,700        
Expenses         400 900 $ 2,200
Expected agreement term     5 years        
Merck & Co.              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Maximum amount that may be credited towards any amount due from collaborator for third-party license income received by the Company       $ 60,000      
Percentage of third-party license income received by the Company that is credited towards any amount due from collaborator       15.00%      
GSK Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Number of optional additional targets | person   2          
Number of development candidates | person   1          
Number of units of accounting in connection of agreements | item   2          
Remaining performance obligation         $ 0    
Maximum royalty percentage on net sales         5.00%    
Alliance revenue         $ 1,100    
Deferred revenue         1,300 $ 100  
Deferred revenue, current portion         1,100    
Expected agreement term   27 months          
GSK Agreement | License, Research, Clinical Development and Commercialization              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments   $ 100,000     100,000    
GSK Agreement | Research and Development Plans and Designation of Development Candidates              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments         9,000    
GSK Agreement | Clinical and Commercial Milestones              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments         $ 89,000    
GSK Agreement | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Anticipated initial collaboration term   4 years          
Number of optional additional targets | item         2    
GSK Agreement | Minimum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Anticipated initial collaboration term   2 years          
Vivelix | Maximum              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments $ 140,000            
Vivelix | Maximum | Back-up compounds              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments 52,500            
Vivelix | Maximum | Development and Regulatory Milestones              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments 65,000            
Vivelix | Maximum | Development and Regulatory Milestones | Back-up compounds              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments 35,000            
Vivelix | Maximum | Sales Milestones              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments 75,000            
Vivelix | Maximum | Sales Milestones | Back-up compounds              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Milestone payments 17,500            
Up-front Payment Arrangement | GSK Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Upfront payment received under collaboration agreement         $ 2,500    
Up-front Payment Arrangement | Vivelix              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Upfront payment received under collaboration agreement $ 15,000            
R&D Services Unit of Accounting | GSK Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Upfront payment received under collaboration agreement   $ 2,500          
JSC Deliverable | GSK Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions              
Upfront payment received under collaboration agreement   $ 0