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Subsequent Events (Details) - USD ($)
$ / shares in Units, $ in Millions
Oct. 28, 2016
Oct. 13, 2016
Feb. 19, 2015
Sep. 30, 2016
Dec. 31, 2015
Subsequent Events          
Stock issued (in shares)     23,000,000    
Common stock, price per share     $ 3.75    
Gross proceeds from offering of common stock     $ 86.3    
Net proceeds from offering of common stock   $ 48.9 $ 80.6    
Common stock shares held       121,411,000 121,265,000
Baker Bros. Advisors LP | Directors          
Subsequent Events          
Stock issued (in shares)     5,333,333    
Common stock, price per share     $ 3.75    
Subsequent Events          
Subsequent Events          
Stock issued (in shares) 1,225,243 25,000,000      
Common stock, price per share   $ 2.00      
Gross proceeds from offering of common stock   $ 50.0      
Net proceeds from offering of common stock   $ 48.9      
Period granted by the Company to underwriters to purchase additional shares 30 days        
Subsequent Events | Investment funds | Directors          
Subsequent Events          
Stock issued (in shares)   5,125,000      
Common stock, price per share   $ 2.00      
Subsequent Events | Baker Bros. Advisors LP          
Subsequent Events          
Common stock shares held   10,272,314      
Subsequent Events | Baker Bros. Advisors LP | Warrants          
Subsequent Events          
Warrant exercise price per share   $ 0.47      
Subsequent Events | Baker Bros. Advisors LP | Warrants | Maximum          
Subsequent Events          
Shares of common stock that may be purchased upon exercise of warrants   20,316,327      
Subsequent Events | Baker Bros. Advisors LP | Pre-funded Warrants          
Subsequent Events          
Warrant exercise price per share   $ 0.01      
Subsequent Events | Baker Bros. Advisors LP | Pre-funded Warrants | Maximum          
Subsequent Events          
Shares of common stock that may be purchased upon exercise of warrants   22,151,052      
Subsequent Events | Pillar Invest Corporation          
Subsequent Events          
Common stock shares held   20,346,942      
Subsequent Events | Pillar Invest Corporation | Warrants | Maximum          
Subsequent Events          
Shares of common stock that may be purchased upon exercise of warrants   11,962,731      
Warrant exercise price per share   $ 1.46      
Subsequent Events | Pillar Invest Corporation | Warrants | Minimum          
Subsequent Events          
Warrant exercise price per share   $ 0.47