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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 LynMHsAb519bbgVRCs9G8oQkqAL5h67+B6bFRyRB8joY4UB2gI3dkRaePrQjwRjy
 Z3jpFd1NhqlxqjGmyT0jYA==

<SEC-DOCUMENT>0001209191-04-002144.txt : 20040108
<SEC-HEADER>0001209191-04-002144.hdr.sgml : 20040108
<ACCEPTANCE-DATETIME>20040108150246
ACCESSION NUMBER:		0001209191-04-002144
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040106
FILED AS OF DATE:		20040108

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ZAMECNIK PAUL C
		CENTRAL INDEX KEY:			0001195564

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-31918
		FILM NUMBER:		04515311

	MAIL ADDRESS:	
		STREET 1:		101 CHESTNUT STREET
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02108

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HYBRIDON INC
		CENTRAL INDEX KEY:			0000861838
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				043072298
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		345 VASSAR STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6176795500

	MAIL ADDRESS:	
		STREET 1:		345 VASSAR STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?><ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>4</documentType><periodOfReport>2004-01-06</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000861838</issuerCik><issuerName>HYBRIDON INC</issuerName>        <issuerTradingSymbol>hby</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001195564</rptOwnerCik><rptOwnerName>ZAMECNIK PAUL C</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>101 CHESTNUT STREET</rptOwnerStreet1><rptOwnerStreet2></rptOwnerStreet2><rptOwnerCity>BOSTON</rptOwnerCity><rptOwnerState>MA</rptOwnerState><rptOwnerZipCode>02108</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther></reportingOwnerRelationship></reportingOwner><nonDerivativeTable><nonDerivativeTransaction><securityTitle><valu
e>Common Stock</value></securityTitle><transactionDate><value>2004-01-06</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>P</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>2580.0000</value></transactionShares><transactionPricePerShare><value>0.9690</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>696931.0000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction></nonDerivativeTable><footnotes></footnotes><remarks></remarks><ownerSignature><signatureName>Paul C. Zamecnik</signatureNa
me><signatureDate>2004-01-07</signatureDate></ownerSignature></ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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