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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KE1T5K14aBYdKG3y2hq3Mrw71vKBSxiDeXKev8XAm8x9Zw2T2rLHF6SmM2AvBjQd
 GQPQErIcYV+zfDL2UcxrLg==

<SEC-DOCUMENT>0001209191-03-020565.txt : 20030908
<SEC-HEADER>0001209191-03-020565.hdr.sgml : 20030908
<ACCEPTANCE-DATETIME>20030908145516
ACCESSION NUMBER:		0001209191-03-020565
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030828
FILED AS OF DATE:		20030908

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HYBRIDON INC
		CENTRAL INDEX KEY:			0000861838
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				043072298
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		345 VASSAR STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6176795500

	MAIL ADDRESS:	
		STREET 1:		345 VASSAR STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ZEIN YOUSSEF EL
		CENTRAL INDEX KEY:			0001193366

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27352
		FILM NUMBER:		03885876

	BUSINESS ADDRESS:	
		STREET 1:		HYBRIDON INC
		STREET 2:		345 VASSAR STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6176795530

	MAIL ADDRESS:	
		STREET 1:		HYBRIDON INC
		STREET 2:		345 VASSAR STREET
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?><ownershipDocument><schemaVersion>X0201</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-08-28</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000861838</issuerCik><issuerName>HYBRIDON INC</issuerName>        <issuerTradingSymbol>hybn</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001193366</rptOwnerCik><rptOwnerName>ZEIN YOUSSEF EL</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>C/O HYBRIDON, INC.</rptOwnerStreet1><rptOwnerStreet2>345 VASSAR STREET</rptOwnerStreet2><rptOwnerCity>CAMBRIDGE</rptOwnerCity><rptOwnerState>MA</rptOwnerState><rptOwnerZipCode>02139</rptOwnerZipCode><rptOwnerStateDescription></rptOwnerStateDescription></reportingOwnerAddress><reportingOwnerRelationship><isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther></reportingOwnerRelationship></reportingOwner><nonDerivativeTable><nonDerivativeTransaction>
<securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-08-28</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>5500381</value></transactionShares><transactionPricePerShare><value>0.73</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>5500381</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>I</value></directOrIndirectOwnership><natureOfOwnership><value>By Optima Life Sciences Limited</value></natureOfOwnership></ownershipNature></nonDerivativeTransaction><nonDerivativeHolding><sec
urityTitle><value>Common Stock</value></securityTitle><postTransactionAmounts><sharesOwnedFollowingTransaction><value>1827835</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeHolding></nonDerivativeTable><derivativeTable><derivativeTransaction><securityTitle><value>Common Stock Warrants (right to buy)</value></securityTitle><conversionOrExercisePrice><value>1</value></conversionOrExercisePrice><transactionDate><value>2003-08-28</value></transactionDate><deemedExecutionDate></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>1650114</value></transactionShares><transactionPricePerShare><value>0</value></transactionPricePerShare><transaction
AcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>2003-08-28</value></exerciseDate><expirationDate><value>2008-08-28</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>1650114</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>1650114</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>I</value></directOrIndirectOwnership><natureOfOwnership><value>By Optima Life Sciences Limited</value></natureOfOwnership></ownershipNature></derivativeTransaction><derivativeTransaction><securityTitle><value>Common Stock Warrants (right to buy)</value></securityTitle><conversionOrExercisePrice><value>1</value></conversionOrExercisePrice><transactionDate><value>2003-08-28</value></transactionDate><deemedExecutionDate></deemedExecuti
onDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>J</transactionCode><equitySwapInvolved>0</equitySwapInvolved><footnoteId id="F1" /></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>587709</value></transactionShares><transactionPricePerShare><value>0</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>2003-08-28</value></exerciseDate><expirationDate><value>2008-08-28</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>587709</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>587709</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>I</value></directOrIndire
ctOwnership><natureOfOwnership><value>By Pillar Investment Ltd.</value></natureOfOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes><footnote id="F1">Compensation/fee as placement agent</footnote></footnotes><remarks></remarks><ownerSignature><signatureName>Youssef El Zein</signatureName><signatureDate>2003-09-05</signatureDate></ownerSignature></ownershipDocument>

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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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