POWER OF ATTORNEY

The undersigned, Youssef El Zein, hereby constitutes and appoints each of Mark

J.   Casey,   Louis  J.  Arcudi  and  Bonnie  E.  McManus  signing  singly,  the
undersigned's true and lawful attorney-in-fact to:

     1.  execute  for  and  on  behalf  of the undersigned, in the undersigned's
capacity as Director of Idera Pharmaceuticals, Inc. ("Company"), Forms 3, 4, and
5 in accordance with Section 16 of the Securities Exchange Act of 1934 and the


rules thereunder;

     2.  do  and  perform  any and all acts for and on behalf of the undersigned
which may be necessary or desirable to complete and execute any such Forms 3, 4,
or  5,  complete and execute any amendment(s) thereto, and timely file such form
with the United States Securities and Exchange Commission and any stock exchange
or similar authority; and

     3.  take  any  other  action  of any type whatsoever in connection with the
foregoing  which, in the opinion of such attorney-in-fact, may be of benefit to,
in  the  best  interest  of,  or  legally required by, the undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf of the
undersigned  pursuant  to this Power of Attorney shall be in such form and shall
contain  such  terms and conditions as such attorney-in-fact may approve in such
attorney-in-fact's discretion.

The  undersigned  hereby  grants  to  each  such attorney-in-fact full power and
authority  to  do  and perform any and every act and thing whatsoever requisite,
necessary,  or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could  do  if personally present, with full power of substitution or revocation,
hereby  ratifying  and  confirming  all  that  such  attorney-in-fact,  or  such
attorney-in-fact's  substitute  or substitutes, shall lawfully do or cause to be
done  by  virtue  of  this  power  of  attorney and the rights and powers herein
granted.  The  undersigned acknowledges that the foregoing attorneys-in-fact, in
serving  in  such  capacity at the request of the undersigned, are not assuming,
nor is the Company assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Securities Exchange Act of 1934.

This  Power  of  Attorney  shall  remain  in  full  force  and  effect until the
undersigned  is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's  holdings of and transactions in securities issued by the Company,
unless  earlier  revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

IN  WITNESS  WHEREOF,  the  undersigned  has caused this Power of Attorney to be
executed as of this 8th day of June 2017.

/s/ Youssef El Zein
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Youssef El Zein