Mail Stop 4561

      December 21, 2006

Dennis D. Powell
Senior Vice President and
Chief Financial Officer
Cisco Systems, Inc.
170 West Tasman Drive
San Jose, CA 95134-1706

	Re:	Cisco Systems, Inc.
   Form 10-K for the Fiscal Year Ended
   July 29, 2006
		Filed September 18, 2006
		File No. 000-18225

Dear Mr. Powell:

	We have the following additional comments regarding your Form
10-K.

1. We note from your company website and a public report that you
may
have operations in Syria, a country identified as a state sponsor
of
terrorism by the State Department and subject to export controls
and
sanctions administered by the Commerce Department`s Bureau of
Industry and Security and the Treasury Department`s Office of
Foreign
Assets Control.  Your Form 10-K discloses that you have operations
in
the Middle East but does not contain information relating
specifically to operations in or contacts with Syria.  Please
describe your current, past and anticipated operations in and
contacts with Syria, if any, including through subsidiaries,
affiliates and other direct and indirect arrangements.






2. Discuss the materiality to you of the operations and contacts
described in your response to the foregoing comment, in light of
Syria`s status as a state sponsor of terrorism.  Please also
discuss
whether the operations or contacts constitute a material
investment
risk to your security holders.  Please describe the extent to
which
the government of Syria or entities controlled by it are
intermediaries or receive financing in connection with your
operations associated with that country.

3. Your materiality analysis should address materiality in
quantitative terms, including the approximate dollar amount of
revenues, assets and liabilities associated with Syria.  Please
address materiality in terms of qualitative factors that a
reasonable
investor would deem important in making an investment decision,
including the potential impact of corporate activities upon your
reputation and share value.

For example, we note that Arizona and Louisiana have adopted
legislation requiring their state retirement systems to prepare
reports regarding state pension fund assets invested in, and/or
permitting divestment of state pension fund assets from, companies
that do business with countries identified as state sponsors of
terrorism.  The Missouri Investment Trust has established an
equity
fund for the investment of certain state-held monies that screens
out
stocks of companies that do business with U.S.-designated state
sponsors of terrorism.  We note also that the Pennsylvania
legislature has adopted a resolution directing its Legislative
Budget
and Finance Committee to report annually to the General Assembly
regarding state funds invested in companies that have ties to
terrorist-sponsoring countries.  Your materiality analysis should
address the potential impact of the investor sentiment evidenced
by
such actions directed toward companies operating in Syria.

Please also address the impact of your regulatory compliance
programs, such as programs designed to prevent terrorism funding,
which cover operations and contacts associated with Syria, and any
internal risk assessment undertaken in connection with business in
Syria.

      * * * * *

      You may contact me at (202) 551-3730 if you have questions
regarding these comments.

							Sincerely,


							Barbara C. Jacobs
							Assistant Director
Dennis D. Powell
Cisco Systems, Inc.
December 21, 2006
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