-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 C23qrFjulw+Aql5JsaosAKT8e3hpWGK5DiyBu0/EL/X1eWETB4bzXb69jsnL4Aad
 4FLJzbpyUoU1ZdiPdPKMvA==

<SEC-DOCUMENT>0000947871-06-001040.txt : 20060605
<SEC-HEADER>0000947871-06-001040.hdr.sgml : 20060605
<ACCEPTANCE-DATETIME>20060605102757
ACCESSION NUMBER:		0000947871-06-001040
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060531
FILED AS OF DATE:		20060605
DATE AS OF CHANGE:		20060605

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ORBIMED CAPITAL II LLC
		CENTRAL INDEX KEY:			0001281668
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-15803
		FILM NUMBER:		06885022

	MAIL ADDRESS:	
		STREET 1:		787 THIRD AVE
		STREET 2:		30TH FL
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ISALY SAMUEL D
		CENTRAL INDEX KEY:			0001055949

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-15803
		FILM NUMBER:		06885023

	BUSINESS ADDRESS:	
		STREET 1:		787 THIRD AVE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10010
		BUSINESS PHONE:		2127396400

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AVANIR PHARMACEUTICALS
		CENTRAL INDEX KEY:			0000858803
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330314804
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			0930

	BUSINESS ADDRESS:	
		STREET 1:		11388 SORRENTO VALLEY ROAD
		STREET 2:		STE 200
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		8586225200

	MAIL ADDRESS:	
		STREET 1:		11388 SORRENTO VALLEY ROAD
		STREET 2:		SUITE 200
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	LIDAK PHARMACEUTICALS
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ORBIMED ADVISORS LLC
		CENTRAL INDEX KEY:			0001055951
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-15803
		FILM NUMBER:		06885024

	BUSINESS ADDRESS:	
		STREET 1:		767 3RD AVENUE
		STREET 2:		30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
		BUSINESS PHONE:		2126845700

	MAIL ADDRESS:	
		STREET 1:		767 3RD AVENUE
		STREET 2:		30TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10017
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>form4a_060506-avanirex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2006-05-31</periodOfReport>

    <dateOfOriginalSubmission>2006-06-02</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000858803</issuerCik>
        <issuerName>AVANIR PHARMACEUTICALS</issuerName>
        <issuerTradingSymbol>AVN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001055951</rptOwnerCik>
            <rptOwnerName>ORBIMED ADVISORS LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>767 THIRD AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10017</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001055949</rptOwnerCik>
            <rptOwnerName>ISALY SAMUEL D</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>767 THIRD AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10017</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001281668</rptOwnerCik>
            <rptOwnerName>ORBIMED CAPITAL II LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>787 THIRD AVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10017</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2006-05-31</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>629121</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>9.79</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1706137</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>FN</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">This Form 4 is an amendment of and replaces that Form 4 filed by the same parties on June 2, 2006. The disposition of
 securities described herein represents a distribution by Caduceus Private Investments II, LP (&quot;Caduceus&quot;) and Caduceus
 Private Investments II (QP), LP (&quot;Caduceus QP&quot;) of these securities to the limited partners in Caduceus and Caduceus QP.
 This distribution thus does not represent a change to the ultimate owners of the securities and may instead be viewed simply
 as a transfer into the hands of these ultimate owners.</footnote>
        <footnote id="F2">As of 5/31/06, Reporting Persons held 1,706,137 shares of Class A common stock, on behalf of other persons who have the right
 to receive or the power to direct the receipt of dividends from, or proceeds from sale of, such securities.  Of this amount,
 Caduceus, Caduceus QP and UBS Juniper Crossover Fund, LLC (&quot;Juniper&quot;) directly hold 1,090,968, 421,981 and 193,188 shares,
 respectively.  OrbiMed Advisors LLC (&quot;Advisors&quot;), pursuant to its authority under its investment advisory contracts with
 Juniper, may be considered to hold indirectly 193,188 shares of common stock and OrbiMed Capital GP II LLC (&quot;Capital&quot;),
 pursuant to its authority under its investment advisory contract with Caduceus and Caduceus QP, may be considered to hold
 indirectly 1,512,949 shares of common stock.</footnote>
        <footnote id="F3">Advisors is a registered adviser under the Investment Advisers Act of 1940, as amended, that acts as an investment adviser to
 certain collective investment funds which hold Shares of the Issuer.  Samuel D. Isaly, a natural person, owns controlling
 interests in Advisors and Capital.  Advisors acts as investment adviser to Juniper.  Capital acts as general partner to
 Caduceus and Caduceus QP.  Pursuant to certain agreements and relationships, Advisors and Capital have discretionary
 investment management authority with respect to the assets of Caduceus, Caduceus QP, and Juniper.  Such authority includes
 the power to vote and otherwise dispose of securities purchased by Caduceus, Caduceus QP and Juniper.  The Reporting Person
 may be deemed to be a director of the issuer by virtue of its having nominated a representative, now Jonathan Silverstein,
 to serve on the issuer's board of directors.</footnote>
        <footnote id="F4">The Reporting Persons disclaim beneficial ownership of the these securities except to the extent of their pecuniary interest
 therein, and this report shall not be deemed an admission that the Reporting Person are the beneficial owners of such
 securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purposes.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Samuel D. Isaly</signatureName>
        <signatureDate>2006-06-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----