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Note 7 - Patents - Summary of Patents (Details) - USD ($)
Mar. 31, 2022
Dec. 31, 2021
Patents, cost $ 1,377,863 $ 1,377,863
Patents, accumulated amortization (1,113,671) (1,100,244)
Patents-foundation intellectual property 264,192 277,619
Foundation Intellectual Property Patents [Member]    
Patents, cost 1,377,863 1,377,863
Patents, accumulated amortization (1,113,671) (1,100,244)
Patents-foundation intellectual property $ 264,192 $ 277,619