8-K

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934

Date of Report (Date of earliest event reported) January 29, 2008

MILESTONE SCIENTIFIC INC.

(Exact name of Registrant as specified in its charter)

Delaware	0-26284	13-3545623
(State or other jurisdiction of incorporation)	(Commission File Number)	(IRS Employer Identification No.)

220 South Orange Avenue, Livingston Corporate Park, Livingston, New Jersey 07039
(Address of principal executive office) (Zip Code)

Registrant’s telephone number, including area code (973) 535-2717

N/A

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 5.02: Departure of Directors or Principal Officers; Election of Directors; Appointment of Principal Officers.

     On January 29, 2008, we appointed Joseph D’Agostino as Acting Chief Financial Officer to replace Arthur Goldberg, whose resignation was previously reported. From May 2007 until his appointment at Milestone, Mr. D’Agostino served as Senior Vice President and Treasurer of Summit Global Logistics, Inc., a publicly traded, full service, international freight forwarder and customs broker with operations in the United States and China. From April 2002 to May 2007, Mr. D’Agostino was Vice-President and CFO of Haynes Security Inc., an electronic and manned security solutions company serving government agencies and commercial enterprises. From June 1983 to April 2002, Mr. D’Agostino was Executive Vice President of Finance and Administration of Casio Inc., the U.S. subsidiary of Casio Computer Co., Ltd., a leading manufacturer of consumer electronics with subsidiaries throughout the world. Prior to 1983, Mr. D’Agostino also served as Manager of Accounting and Auditing for the National Office of Main Hurdman, CPAs (KPMG) in New York City. Mr. D’Agostino received his B.A. in Science from William Paterson University in New Jersey and is a Certified Public Accountant for the State of New Jersey.

Item 8.01: Other Matters.

     On January 30, 2008, we issued a press release, a copy of which is attached hereto as Exhibit 99.1.

Item 9.01: Financial Statements and Exhibits

          (d) Exhibits:

               99.1 Press Release dated January 30, 2008.

SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	MILESTONE SCIENTIFIC INC.
	By:	/s/ Joe W. Martin
		Joe W. Martin
Dated: January 30, 2008		Chief Executive Officer

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EX-99.1

Exhibit 99.1

MILESTONE SCIENTIFIC NAMES JOSEPH D’AGOSTINO
AS ACTING CHIEF FINANCIAL OFFICER

LIVINGSTON, N.J. — (PR NEWSWIRE) — January 30, 2008 - Milestone Scientific Inc. (OTCBB:MLSS), the recognized leader in advanced injection technologies, today announced that Joseph D’Agostino, CPA, has been appointed as the Company’s new Acting Chief Financial Officer, replacing former Acting CFO, Arthur Goldberg. D’Agostino will serve in this role for a period of approximately six months, and then subject to mutual consent and Board approval at that time, he will assume the title of Chief Financial Officer thereafter.

D’Agostino brings Milestone a wealth of finance and accounting experience earned over 25 years serving both publicly and privately held companies. A results-oriented and decisive leader, he has specific proven expertise in treasury and cash management, strategic planning, information technology, internal controls, Sarbanes-Oxley compliance, operations and financial and tax accounting. Immediately prior to joining Milestone, D’Agostino served as Senior Vice President and Treasurer of Summit Global Logistics, a publicly traded, full service international freight forwarder and customs broker with operations in the United States and China.

Previous executive posts also included Executive Vice President and CFO of Haynes Security, Inc., a leading electronic and manned security solutions company serving government agencies and commercial enterprises; Executive Vice President of Finance and Administration for Casio, Inc., the U.S. subsidiary of Casio Computer Co., Ltd., a leading manufacturer of consumer electronics with subsidiaries throughout the world; and Manager of Accounting and Auditing for Main Hurdman’s (KPMG) national office in New York City. D’Agostino is a Certified Public Accountant and holds memberships in the American Institute of CPA’s, New Jersey Society of CPA’s, Financial Executive Institute, Consumer Electronics Industry Association and Homeland Security Industry Association. He is a graduate of William Paterson University where he earned a Bachelor of Arts degree in Science.

“Joseph is a highly qualified executive with an impressive skill set and a proven track record for building financially sound organizations with strong internal control environments. Joseph is enthusiastic and has a passion for success. He will be an excellent complementary addition to our team,” stated Joe Martin, Milestone’s Chief Executive Officer.

About Milestone Scientific Inc.

Headquartered in Livingston, New Jersey, Milestone Scientific is engaged in pioneering proprietary, highly innovative technological solutions for the medical and dental markets. Central to the Company’s IP platform and product development strategy is its patented CompuFlo™ technology for the improved and painless delivery of local anesthetic. Specifically, CompuFlo is a computer-controlled, pressure sensitive infusion, perfusion, suffusion and aspiration technology, which provides real-time readouts of pressures, fluid densities and flow rates, enabling the advanced delivery and removal of a wide array of fluids. The Single Tooth Anesthesia (STA™) computer-controlled local anesthesia delivery system which uses this technology provides dentists with audible and visual signals as to in-tissue pressure. Milestone’s existing painless injection systems are currently sold in 25 countries. For more information on these and other innovative Milestone products, please visit the Company’s web site found at www.milesci.com.

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Safe Harbor Statement

This press release contains forward-looking statements regarding the timing and financial impact of the Milestone’s ability to implement its business plan, expected revenues and future success. These statements involve a number of risks and uncertainties and are based on assumptions involving judgments with respect to future economic, competitive and market conditions and future business decisions, all of which are difficult or impossible to predict accurately and many of which are beyond Milestone’s control. Some of the important factors that could cause actual results to differ materially from those indicated by the forward-looking statements are general economic conditions, failure to achieve expected revenue growth, changes in our operating expenses, adverse patent rulings, FDA or legal developments, competitive pressures, changes in customer and market requirements and standards, and the risk factors detailed from time to time in Milestone’s periodic filings with the Securities and Exchange Commission, including without limitation, Milestone’s Annual Report on Form 10-KSB for the year ended December 31, 2006. The forward looking-statements in this press release are based upon management’s reasonable belief as of the date hereof. Milestone undertakes no obligation to revise or update publicly any forward-looking statements for any reason.

FOR MORE INFORMATION, PLEASE CONTACT:
Elite Financial Communications Group, LLC
Dodi Handy, President and CEO, or Daniel Conway, Chief Strategist
407-585-1080 or via email at mlss@efcg.net

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