Collaboration and License Agreements - Vertex (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Feb. 28, 2023	Dec. 31, 2022
Collaborative Agreements disclosures
Aggregate amount of transaction price allocated to remaining performance obligations	$ 63,900		$ 63,900
Revenue from contract with customer	113,425	$ 15,375	246,447	$ 67,615
Amount of obligation included in long-term deferred revenue	26,718		26,718			$ 36,355
License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer	$ 51	$ 7,382	15,122	$ 45,247
Vertex | Upfront payment
Collaborative Agreements disclosures
License agreement upfront payment receivable					$ 15,000
License agreement, target selection fees and development, regulatory and commercial milestone payments receivable					$ 337,000
Revenue from contract with customer			15,000
Vertex | License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer			$ 15,000