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Collaboration and License Agreements - Novartis (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022	Dec. 31, 2022	Aug. 31, 2022	Dec. 31, 2021
Collaborative Agreements disclosures
Revenue from contract with customer	$ 113,425	$ 15,375	$ 246,447	$ 67,615
Contract with customer liability	63,904	53,811	63,904	53,811	$ 50,211		$ 92,068
Revenue recognized, previously deferred	3,929	7,337	9,534	43,961
Milestone payments plus royalties on the commercial sales \| Novartis
Collaborative Agreements disclosures
Potential milestone payment	199,500		199,500
Revenue recognized, previously deferred			5,000
License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer	51	$ 7,382	15,122	45,247
License and milestone fees \| Novartis
Collaborative Agreements disclosures
Deferred revenue	700		700
Revenue recognized, previously deferred				2,800
Research and development support
Collaborative Agreements disclosures
Revenue from contract with customer	$ 855		$ 1,310	831
Research and development support \| Novartis
Collaborative Agreements disclosures
Revenue from contract with customer				$ 2,800
Deferred revenue						$ 2,800