Collaboration and License Agreements - Vertex (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Feb. 28, 2023	Dec. 31, 2022
Collaborative Agreements disclosures
Aggregate amount of transaction price allocated to remaining performance obligations	$ 44,600		$ 44,600
Revenue from contract with customer	83,153	$ 14,162	133,022	$ 52,240
Amount of obligation included in long-term deferred revenue	30,217		30,217			$ 36,355
License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer	$ 40	$ 6,973	15,071	$ 37,865
Vertex | Upfront payment
Collaborative Agreements disclosures
License agreement upfront payment receivable					$ 15,000
License agreement, target selection fees and development, regulatory and commercial milestone payments receivable					$ 337,000
Revenue from contract with customer			15,000
Vertex | License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer			$ 15,000