Collaboration and License Agreements - Vertex (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Feb. 28, 2023	Dec. 31, 2022
Collaborative Agreements disclosures
Aggregate amount of transaction price allocated to remaining performance obligations	$ 47,500
Revenue from contract with customer	49,869	$ 38,078
Amount of obligation included in long-term deferred revenue	34,055			$ 36,355
License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer	15,031	$ 30,892
Vertex | Upfront payment
Collaborative Agreements disclosures
License agreement upfront payment receivable			$ 15,000
License agreement, target selection fees and development, regulatory and commercial milestone payments receivable			$ 337,000
Revenue from contract with customer	15,000
Vertex | License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer	$ 15,000