Income Taxes - Deferred Tax Assets Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net operating loss carryforwards	$ 115,047	$ 264,773
Research and development tax credit carryforwards	103,155	92,832
Property and other intangible assets	1,452	1,150
Deferred revenue	14,561	25,153
Stock-based compensation	18,783	12,195
Operating lease liability	4,421	5,170
Other liabilities	3,144	1,737
Royalty sale	8,393	10,247
Sec 174 R&E capitalization	68,150
Total deferred tax assets	337,106	413,257
Deferred tax liabilities:
Operating lease right of use asset	(2,967)	(3,386)
Royalty sale transaction costs	(107)	(158)
Total deferred tax liabilities	3,074	3,544
Valuation allowance	$ (334,032)	$ (409,713)