CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues:
Total revenues	$ 108,782	$ 69,856	$ 132,299
Cost and operating expenses:
Cost of sales	176
Research and development	213,370	151,117	114,592
Selling, general and administrative	116,129	43,812	38,600
Restructuring charge			1,487
Total cost and operating expenses	329,675	194,929	154,679
Loss from operations	(220,893)	(125,073)	(22,380)
Investment income, net	4,341	51	729
Non-cash interest expense on liability related to the sale of future royalties and convertible senior notes	(4,165)	(13,103)	(23,107)
Interest expense on convertible senior notes		(47)	(95)
Other (expense) income, net	(994)	(1,131)	481
Net loss before income taxes	(221,711)	(139,303)	(44,372)
Income tax expense	1,218	0	0
Net loss	$ (222,929)	$ (139,303)	$ (44,372)
Basic net loss per common share	$ (0.88)	$ (0.68)	$ (0.25)
Diluted net loss per common share	$ (0.88)	$ (0.68)	$ (0.25)
Basic weighted average common shares outstanding (in shares)	253,631	206,147	176,153
Diluted weighted average common shares outstanding (in shares)	253,631	206,147	176,153
Total comprehensive loss	$ (222,929)	$ (139,303)	$ (44,372)
License and milestone fees
Revenues:
Total revenues	76,027	22,650	63,742
Non-cash royalty revenue related to the sale of future royalties
Revenues:
Total revenues	29,261	46,808	68,529
Research and development support
Revenues:
Total revenues	940	$ 398	$ 28
Product revenue, net
Revenues:
Total revenues	$ 2,554