CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities:
Net loss	$ (163,921)	$ (102,131)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(9,027)	(35,035)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	3,194	10,952
Depreciation and amortization	1,355	1,555
Stock and deferred share unit compensation	14,862	11,042
Change in operating assets and liabilities:
Accounts receivable	4,425	(186)
Unbilled receivable	1,649	(4,695)
Contract asset	3,000	(2,500)
Prepaid and other current assets	(9,392)	(6,429)
Operating lease right-of-use assets	1,583	1,327
Other assets	(4,389)	2,451
Accounts payable	1,689	1,354
Accrued compensation	3,152	98
Other accrued liabilities	23,057	5,153
Deferred revenue	(38,257)	(4,104)
Operating lease liability	(2,583)	(2,394)
Net cash used for operating activities	(169,603)	(123,542)
Cash flows from investing activities:
Purchases of property and equipment	(1,116)	(1,065)
Net cash used for investing activities	(1,116)	(1,065)
Cash flows from financing activities:
Payments upon settlement of convertible senior notes		(1,100)
Proceeds from issuance of common stock under stock plans	1,480	2,032
Proceeds from warrant issuance, net of $181 of transaction costs		29,765
Proceeds from common stock issuance, net of $143 of transaction costs		45,815
Net cash provided by financing activities	1,480	76,512
Net change in cash and cash equivalents	(169,239)	(48,095)
Cash and cash equivalents, beginning of period	478,750	293,856
Cash and cash equivalents, end of period	$ 309,511	$ 245,761