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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 9 Months Ended 12 Months Ended
Jan. 31, 2019
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2015
Liability Related to Sale of Future Royalties        
Non-cash royalty revenue related to the sale of future royalties   $ 9,027 $ 35,035  
KADCYLA        
Liability Related to Sale of Future Royalties        
Percentage of royalty payments if applicable threshold is met       85.00%
IRH | KADCYLA        
Liability Related to Sale of Future Royalties        
Percentage of royalty payments       100.00%
Percentage of royalty payments if applicable threshold is met       15.00%
Transaction costs for royalty agreements       $ 5,900
Change in liability related to sale of future royalties        
Liability related to sale of future royalties, net - beginning balance   41,044    
Proceeds from sale of future royalties, net   200,000   200,000
Royalty payments received and paid   (9,690)    
Non-cash interest expense recognized   3,194    
Liability related to sale of future royalties, net - ending balance   $ 34,548    
Effective annual interest rate   10.50%    
Current effective interest rate   8.7    
IRH | KADCYLA | Maximum        
Liability Related to Sale of Future Royalties        
Royalties threshold       260,000
IRH | KADCYLA | Minimum        
Liability Related to Sale of Future Royalties        
Royalties threshold       $ 235,000
OMERS | KADCYLA        
Liability Related to Sale of Future Royalties        
Percentage of royalty payments 100.00%      
Non-cash royalty revenue related to the sale of future royalties $ 65,200   3,700  
Contingent broker fees 1,500      
Net proceeds from sale of residual rights to receive royalty payments $ 65,200 $ 12,500    
Roche        
Liability Related to Sale of Future Royalties        
Period in arrears to receive royalty reports and payments related to sales of Kadcyla   3 months    
Roche | KADCYLA        
Liability Related to Sale of Future Royalties        
Non-cash royalty revenue related to the sale of future royalties   $ 21,500 $ 38,800