CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (86,166)	$ (64,792)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(5,590)	(31,721)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	2,327	8,201
Depreciation and amortization	931	1,093
Stock and deferred share unit compensation	9,380	7,565
Change in operating assets and liabilities:
Accounts receivable	3,558	28
Unbilled receivable	471	(4,216)
Contract asset	3,000
Prepaid and other current assets	(6,777)	(6,603)
Operating lease right-of-use assets	1,031	866
Other assets	(3,965)	2,100
Accounts payable	(1,249)	2,482
Accrued compensation	(509)	(893)
Other accrued liabilities	12,643	(146)
Deferred revenue	(32,821)	(837)
Operating lease liability	(1,657)	(1,627)
Net cash used for operating activities	(105,393)	(88,500)
Cash flows from investing activities:
Purchases of property and equipment	(514)	(940)
Net cash used for investing activities	(514)	(940)
Cash flows from financing activities:
Proceeds from issuance of common stock under stock plans	1,031	1,664
Proceeds from common stock issuance, net of $106 of transaction costs		33,458
Net cash provided by financing activities	1,031	35,122
Net change in cash and cash equivalents	(104,876)	(54,318)
Cash and cash equivalents, beginning of period	478,750	293,856
Cash and cash equivalents, end of period	$ 373,874	$ 239,538