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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Jan. 31, 2019
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2015
Liability Related to Sale of Future Royalties          
Non-cash royalty revenue related to the sale of future royalties     $ 5,590 $ 31,721  
KADCYLA          
Liability Related to Sale of Future Royalties          
Percentage of royalty payments if applicable threshold is met         85.00%
IRH | KADCYLA          
Liability Related to Sale of Future Royalties          
Percentage of royalty payments         100.00%
Percentage of royalty payments if applicable threshold is met         15.00%
Transaction costs for royalty agreements         $ 5,900
Change in liability related to sale of future royalties          
Liability related to sale of future royalties, net - beginning balance     41,044    
Proceeds from sale of future royalties, net     200,000   200,000
Royalty payments received and paid     (6,537)    
Non-cash interest expense recognized     2,327    
Liability related to sale of future royalties, net - ending balance     $ 36,834    
Effective annual interest rate     10.50%    
Current effective interest rate     10.6    
IRH | KADCYLA | Maximum          
Liability Related to Sale of Future Royalties          
Royalties threshold         260,000
IRH | KADCYLA | Minimum          
Liability Related to Sale of Future Royalties          
Royalties threshold         $ 235,000
OMERS | KADCYLA          
Liability Related to Sale of Future Royalties          
Percentage of royalty payments 100.00%        
Non-cash royalty revenue related to the sale of future royalties $ 65,200 $ 500      
Contingent broker fees 1,500        
Net proceeds from sale of residual rights to receive royalty payments $ 65,200 $ 8,000      
Roche          
Liability Related to Sale of Future Royalties          
Period in arrears to receive royalty reports and payments related to sales of Kadcyla     3 months    
Roche | KADCYLA          
Liability Related to Sale of Future Royalties          
Non-cash royalty revenue related to the sale of future royalties     $ 13,500 $ 32,200