Agreements - Huadong (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended		12 Months Ended
	Dec. 31, 2021	Oct. 31, 2020	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020
Collaborative Agreements disclosures
Revenue from contract with customer			$ 38,078	$ 15,706
Revenue recognized, previously deferred			25,760	72
Deferred revenue	$ 92,068		70,111	110,037	$ 92,068	$ 110,109
Huadong | Development milestones
Collaborative Agreements disclosures
Deferred revenue			6,900
Upfront payment | Huadong
Collaborative Agreements disclosures
Revenue from contract with customer		$ 40,000
Upfront payment | Huadong | Development milestones
Collaborative Agreements disclosures
Revenue recognized, previously deferred					45,000
License and milestone fees
Collaborative Agreements disclosures
Revenue from contract with customer			30,892	$ 157
License and milestone fees | Huadong | Development milestones
Collaborative Agreements disclosures
Revenue from contract with customer	5,000
Revenue recognized, previously deferred			$ 21,600
Deferred revenue	$ 28,500				$ 28,500
License and milestone fees | Huadong | Sales milestones
Collaborative Agreements disclosures
Potential milestone payment		$ 265,000
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-12-01 | License and milestone fees | Huadong | Development milestones
Collaborative Agreements disclosures
Remaining performance obligation, expected timing of satisfaction	2 years				2 years