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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Cash flows from operating activities:      
Net loss $ (104,133) $ (168,843) $ (96,012)
Adjustments to reconcile net loss to net cash used for operating activities:      
Non-cash royalty revenue related to sale of future royalties (47,415) (32,154) (28,142)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes 16,879 10,631 13,682
Non-cash debt conversion expense     22,915
Depreciation and amortization 4,028 7,411 5,963
Loss (gain) on sale/disposal of fixed assets and impairment charges 1,689 115 239
Operating lease right-of-use asset impairment 694    
Stock and deferred share unit compensation 14,167 16,807 11,325
Deferred rent   (95) 91
Change in operating assets and liabilities:      
Accounts receivable (5,799) 948 (623)
Unbilled revenue/reimbursement (384) 1,963 4,198
Inventory   1,038 1,154
Contract asset (3,131) (500)  
Prepaid and other current assets (963) (1,495) 2,419
Operating lease right-of-use assets 1,331    
Other assets (75) 88 (777)
Accounts payable (1,045) 2,667 771
Accrued compensation (2,189) 323 4,527
Other accrued liabilities (6,146) 3,839 4,375
Deferred revenue 46,630 (9,165) 61,540
Operating lease liability (2,505)    
Net cash (used) provided for operating activities (88,367) (166,422) 7,645
Cash flows from investing activities:      
Purchases of property and equipment (2,845) (5,246) (1,116)
Proceeds from sale of equipment 2,312    
Net cash used for investing activities (533) (5,246) (1,116)
Cash flows from financing activities:      
Proceeds from issuance of common stock under stock plans 2,873 4,301 650
Proceeds from common stock issuance, net of $395 and $222 of transaction costs, respectively   162,512 101,663
Fees for debt conversion     (1,699)
Net cash provided by financing activities 2,873 166,813 100,614
Net change in cash and cash equivalents (86,027) (4,855) 107,143
Cash and cash equivalents, beginning of period 262,252 267,107 159,964
Cash and cash equivalents, end of period 176,225 262,252 267,107
Supplemental cash flow information:      
Cash paid during the year for interest $ 95 $ 95 $ 4,685