CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
Cash flows from operating activities:
Net loss	$ (108,947)	$ (127,044)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(32,102)	(22,873)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	11,525	8,203
Depreciation and amortization	3,277	6,192
Loss (gain) on sale/disposal of fixed assets and impairment charges	2,544	(30)
Operating lease right-of-use asset impairment	694
Stock and deferred share unit compensation	10,939	12,282
Deferred rent		(62)
Change in operating assets and liabilities:
Accounts receivable	1,607	534
Unbilled revenue/reimbursement	(2,392)	2,059
Inventory		(900)
Contract asset	500	(500)
Prepaid and other current assets	(499)	(3,353)
Operating lease right-of-use assets	994
Other assets	296	(144)
Accounts payable	(3,751)	1,420
Accrued compensation	2,336	(1,157)
Other accrued liabilities	(6,058)	7,898
Deferred revenue	65,050	(7,662)
Operating lease liability	(1,823)
Net cash used for operating activities	(55,810)	(125,137)
Cash flows from investing activities:
Purchases of property and equipment	(2,762)	(4,220)
Net cash used for investing activities	(2,762)	(4,220)
Cash flows from financing activities:
Proceeds from issuance of common stock under stock plans	811	2,943
Proceeds from common stock issuance, net of $395 of transaction costs		162,512
Net cash provided by financing activities	811	165,455
Net change in cash and cash equivalents	(57,761)	36,098
Cash and cash equivalents, beginning of period	262,252	267,107
Cash and cash equivalents, end of period	$ 204,491	$ 303,205