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Agreements - Novartis (Details)
1 Months Ended 3 Months Ended 9 Months Ended
May 31, 2018
USD ($)
item
Sep. 30, 2019
USD ($)
Sep. 30, 2018
USD ($)
Sep. 30, 2019
USD ($)
item
Sep. 30, 2018
USD ($)
Collaborative Agreements disclosures          
Revenue from contract with customer   $ 13,281,000 $ 10,928,000 $ 37,407,000 $ 40,030,000
Novartis          
Collaborative Agreements disclosures          
Number of single-target licenses | item       5  
Number of licenses terminated | item 1        
Novartis | Regulatory milestones          
Collaborative Agreements disclosures          
Potential milestone payment     199,500,000   199,500,000
Upfront payment | Novartis          
Collaborative Agreements disclosures          
Revenue from contract with customer $ 978,000       45,000,000
License and milestone fees          
Collaborative Agreements disclosures          
Revenue from contract with customer   $ 79,000 672,000 $ 5,237,000 13,533,000
Exercise fee | Novartis          
Collaborative Agreements disclosures          
Potential milestone payment     1,000,000   1,000,000
Research and development support          
Collaborative Agreements disclosures          
Revenue from contract with customer     $ 388,000 $ 68,000 $ 1,159,000