CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
ASSETS
Cash and cash equivalents	$ 204,491	$ 262,252
Accounts receivable	94	1,701
Unbilled revenue/reimbursement	3,009	617
Contract asset	0	500
Non-cash royalty receivable	13,126	9,249
Prepaid and other current assets	4,961	4,462
Total current assets	225,681	278,781
Property and equipment, net of accumulated depreciation	9,118	12,891
Operating lease right-of-use assets	15,924
Other assets	3,413	3,709
Total assets	254,136	295,381
LIABILITIES AND SHAREHOLDERS (DEFICIT) EQUITY
Accounts payable	7,227	11,365
Accrued compensation	13,232	11,796
Other accrued liabilities	14,040	20,465
Current portion of deferred lease incentive		837
Current portion of liability related to the sale of future royalties, net of deferred financing costs of $707 and $753, respectively	35,985	25,880
Current portion of operating lease liability	2,873
Current portion of deferred revenue	14,817	317
Total current liabilities	88,174	70,660
Deferred lease incentive, net of current portion		4,675
Deferred revenue, net of current portion	131,035	80,485
Operating lease liability - net of current portion	22,578
Convertible 4.5% senior notes, net of deferred financing costs of $25 and $36, respectively	2,075	2,064
Liability related to the sale of future royalties, net of current portion and deferred financing costs of $977 and $1,536, respectively	95,529	122,345
Other long-term liabilities	970	4,180
Total liabilities	340,361	284,409
Commitments and contingencies (Note I)
Shareholders' deficit:
Preferred stock, $.01 par value; authorized 5,000 shares; no shares issued and outstanding
Common stock, $0.01 par value; authorized 200,000 shares; issued and outstanding 149,688 and 149,400 shares as of September 30, 2019 and December 31, 2018, respectively	1,498	1,494
Additional paid-in capital	1,204,559	1,192,813
Accumulated deficit	(1,292,282)	(1,183,335)
Total shareholders (deficit) equity	(86,225)	10,972
Total liabilities and shareholders (deficit) equity	$ 254,136	$ 295,381