CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018
Cash flows from operating activities:
Net loss	$ (87,197)	$ (80,237)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(18,900)	(14,432)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	7,250	5,657
Depreciation and amortization	2,438	5,056
Loss (gain) on sale/disposal of fixed assets and impairment charges	2,404	(30)
Operating lease right-of-use asset impairment	559
Stock and deferred share unit compensation	7,313	7,872
Deferred rent		(59)
Change in operating assets and liabilities:
Accounts receivable	1,701	2,630
Unbilled revenue/reimbursement	(1,857)	2,058
Inventory		(852)
Contract asset	500
Prepaid and other current assets	(2,187)	(6,926)
Operating lease right-of-use assets	664
Other assets	1,859	(640)
Accounts payable	(3,199)	3,871
Accrued compensation	9,238	(2,949)
Other accrued liabilities	(5,346)	1,896
Deferred revenue	65,129	(8,196)
Operating lease liability	(1,179)
Net cash used for operating activities	(20,810)	(85,281)
Cash flows from investing activities:
Purchases of property and equipment	(2,355)	(2,127)
Net cash used for investing activities	(2,355)	(2,127)
Cash flows from financing activities:
Proceeds from issuance of common stock under stock plans	738	2,819
Proceeds from common stock issuance, net of $367 of transaction costs		162,540
Net cash provided by financing activities	738	165,359
Net change in cash and cash equivalents	(22,427)	77,951
Cash and cash equivalents, beginning of period	262,252	267,107
Cash and cash equivalents, end of period	$ 239,825	$ 345,058