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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 6 Months Ended 12 Months Ended
Jan. 31, 2019
Jun. 30, 2019
Jun. 30, 2018
Dec. 31, 2015
Liability Related to Sale of Future Royalties        
Non-cash royalty revenue related to the sale of future royalties   $ 18,900 $ 14,432  
Kadcyla        
Liability Related to Sale of Future Royalties        
Percentage of royalty payments if applicable threshold is met       85.00%
Change in liability related to sale of future royalties        
Liability related to sale of future royalties, net - beginning balance $ 148,225 148,225    
Royalty payments received and paid   (17,718)    
Non-cash interest expense recognized   7,242    
Liability related to sale of future royalties, net - ending balance   137,749    
IRH | Kadcyla        
Liability Related to Sale of Future Royalties        
Percentage of royalty payments       100.00%
Percentage of royalty payments if applicable threshold is met       15.00%
Proceeds from sale of future royalties - net   $ 200,000   $ 200,000
Transaction costs for royalty agreements       5,900
Change in liability related to sale of future royalties        
Effective annual interest rate   8.60%    
Current effective interest rate   10.0    
IRH | Kadcyla | Maximum        
Liability Related to Sale of Future Royalties        
Royalties threshold       260,000
IRH | Kadcyla | Minimum        
Liability Related to Sale of Future Royalties        
Royalties threshold       $ 235,000
OMERS | Kadcyla        
Liability Related to Sale of Future Royalties        
Percentage of royalty payments 100.00%      
Non-cash royalty revenue related to the sale of future royalties $ 65,200      
Contingent broker fees 1,500      
Net proceeds from sale of residual rights to receive royalty payments $ 65,200 $ 0