CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
ASSETS
Cash and cash equivalents	$ 270,396	$ 262,252
Accounts receivable	233	1,701
Unbilled revenue/reimbursement	3,982	617
Contract asset		500
Non-cash royalty receivable	8,514	9,249
Prepaid and other current assets	6,710	4,462
Total current assets	289,835	278,781
Property and equipment, net of accumulated depreciation	13,720	12,891
Operating lease right-of-use assets	16,705
Other assets	3,665	3,709
Total assets	323,925	295,381
LIABILITIES AND SHAREHOLDERS (DEFICIT) EQUITY
Accounts payable	8,777	11,365
Accrued compensation	4,423	11,796
Other accrued liabilities	20,629	20,465
Current portion of deferred lease incentive		837
Current portion of liability related to the sale of future royalties, net of deferred financing costs of $590 and $753, respectively	24,646	25,880
Current portion of operating lease liability	2,634
Current portion of deferred revenue	317	317
Total current liabilities	61,426	70,660
Deferred lease incentive, net of current portion		4,675
Deferred revenue, net of current portion	145,693	80,485
Operating lease liability - net of current portion	24,084
Convertible 4.5% senior notes, net of deferred financing costs of $32 and $36, respectively	2,068	2,064
Liability related to the sale of future royalties, net of current portion and deferred financing costs of $1,500 and $1,536, respectively	117,785	122,345
Other long-term liabilities	473	4,180
Total liabilities	351,529	284,409
Commitments and contingencies (Note I)
Shareholders' deficit:
Preferred stock, $.01 par value; authorized 5,000 shares; no shares issued and outstanding
Common stock, $0.01 par value; authorized 200,000 shares; issued and outstanding 149,425 and 149,400 shares as of March 31, 2019 and December 31, 2018, respectively	1,494	1,494
Additional paid-in capital	1,197,988	1,192,813
Accumulated deficit	(1,227,086)	(1,183,335)
Total shareholders (deficit) equity	(27,604)	10,972
Total liabilities and shareholders (deficit) equity	$ 323,925	$ 295,381