CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2018	Dec. 31, 2017	Jun. 30, 2016
Cash flows from operating activities:
Net loss	$ (78,883)	$ (168,843)	$ (96,012)	$ (144,817)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(12,894)	(32,154)	(28,142)	(25,299)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	8,665	10,631	13,682	20,130
Non-cash debt conversion expense			22,915
Depreciation and amortization	3,074	7,411	5,963	5,327
Loss (gain) on sale/disposal of fixed assets and impairment charges	1,130	115	239	(21)
Stock and deferred share unit compensation	8,337	16,807	11,325	22,248
Deferred rent	88	(95)	91	161
Change in operating assets and liabilities:
Accounts receivable	(1,143)	948	(623)	4,205
Unbilled revenue	(5,369)	1,963	4,198	(695)
Inventory	(1,285)	1,038	1,154	2,028
Contract asset		(500)
Prepaid and other current assets	(505)	(1,495)	2,419	(706)
Other assets	405	88	(777)	(2,456)
Accounts payable	(3,247)	2,667	771	2,649
Accrued compensation	(3,778)	323	4,527	2,378
Other accrued liabilities	960	3,839	4,375	(1,434)
Deferred revenue	747	(9,165)	61,540	(8,318)
Proceeds from landlord for tenant improvements	42			144
Net cash (used) provided by operating activities	(83,656)	(166,422)	7,645	(124,476)
Cash flows from investing activities:
Purchases of property and equipment	(1,406)	(5,246)	(1,116)	(10,376)
Net cash used for investing activities	(1,406)	(5,246)	(1,116)	(10,376)
Cash flows from financing activities:
Proceeds from issuance of common stock under stock plans		4,301	650	5,161
Proceeds from common stock issuance, net of $395 and $222 of transaction costs, respectively		162,512	101,663
Fees for debt conversion			(1,699)
Proceeds from issuance of convertible 4.5% notes, net of $3,392 of transaction costs				96,608
Net cash provided by financing activities		166,813	100,614	101,769
Net change in cash and cash equivalents	(85,062)	(4,855)	107,143	(33,083)
Cash and cash equivalents, beginning of period	245,026	267,107	159,964	278,109
Cash and cash equivalents, end of period	$ 159,964	262,252	267,107	$ 245,026
Supplemental disclosure:
Cash paid during the year for interest		$ 95	$ 4,685