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Agreements - Amgen/Oxford BioTherapeutics (Details)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Dec. 31, 2018
USD ($)
Aug. 31, 2018
item
Feb. 29, 2016
item
Dec. 31, 2015
item
Oct. 31, 2013
USD ($)
May 31, 2013
USD ($)
item
Dec. 31, 2018
USD ($)
Sep. 30, 2018
USD ($)
Jun. 30, 2018
USD ($)
Mar. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Sep. 30, 2017
USD ($)
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Sep. 30, 2016
USD ($)
Jun. 30, 2016
USD ($)
Mar. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Sep. 30, 2015
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Jun. 30, 2016
USD ($)
Dec. 31, 2000
USD ($)
item
Collaborative Agreements disclosures                                                      
Revenue from contract with customer             $ 13,416,000 $ 10,928,000 $ 9,287,000 $ 19,815,000 $ 39,448,000 $ 8,480,000 $ 39,020,000 $ 28,499,000 $ 13,846,000 $ 7,660,000 $ 7,408,000 $ 19,714,000 $ 18,029,000 $ 14,851,000 $ 21,506,000 $ 32,880,000 $ 53,446,000 $ 115,447,000 $ 48,628,000 $ 60,002,000  
Amgen/Oxford BioTherapeutics                                                      
Collaborative Agreements disclosures                                                      
Revenue from contract with customer                                             4,000,000        
Number of single-target licenses | item       4   1                                         3
Number of licenses terminated | item   1 2                                                
Amgen/Oxford BioTherapeutics | Development milestones                                                      
Collaborative Agreements disclosures                                                      
Potential milestone payment         $ 9,000,000                                            
Amgen/Oxford BioTherapeutics | IND application filed                                                      
Collaborative Agreements disclosures                                                      
Revenue from contract with customer $ 1,000,000                                                    
Amgen/Oxford BioTherapeutics | Phase 2 clinical trial                                                      
Collaborative Agreements disclosures                                                      
Potential milestone payment $ 3,000,000           3,000,000                               3,000,000        
Amgen/Oxford BioTherapeutics | Regulatory milestones                                                      
Collaborative Agreements disclosures                                                      
Potential milestone payment         20,000,000                                            
Amgen/Oxford BioTherapeutics | Milestone payments                                                      
Collaborative Agreements disclosures                                                      
Potential milestone payment         5,000,000                                            
Upfront payment | Amgen/Oxford BioTherapeutics                                                      
Collaborative Agreements disclosures                                                      
Revenue from contract with customer                                                     $ 1,000,000
License and milestone fees                                                      
Collaborative Agreements disclosures                                                      
Revenue from contract with customer             1,747,000 672,000 1,321,000 11,540,000 29,580,000 79,000 31,080,000 18,730,000 5,076,000 76,000 76,000 10,077,000 10,692,000 6,070,000 5,152,000 16,762,000 15,280,000 79,469,000 15,305,000 26,915,000  
License and milestone fees | Amgen/Oxford BioTherapeutics                                                      
Collaborative Agreements disclosures                                                      
Revenue from contract with customer         500,000 $ 500,000                                 84,000        
Potential milestone payment         $ 34,000,000                                            
License and milestone fees | Amgen/Oxford BioTherapeutics | IND application filed                                                      
Collaborative Agreements disclosures                                                      
Revenue from contract with customer                                                   1,000,000  
Research and development support                                                      
Collaborative Agreements disclosures                                                      
Revenue from contract with customer             $ 218,000 $ 388,000 $ 388,000 $ 383,000 $ 452,000 $ 650,000 $ 902,000 $ 1,478,000 $ 1,427,000 $ 1,354,000 $ 1,335,000 $ 1,059,000 $ 848,000 $ 772,000 2,781,000 $ 1,620,000 1,377,000 3,482,000 $ 5,175,000 4,014,000  
Costs of services and materials                                         $ 22,000            
Research and development support | Amgen/Oxford BioTherapeutics                                                      
Collaborative Agreements disclosures                                                      
Costs of services and materials                                             $ 0 $ 0   $ 15,000