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Summary of Significant Accounting Policies - Inventory (Details) - USD ($)
3 Months Ended 6 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Jun. 30, 2016
Jan. 02, 2018
Inventory                                          
Raw materials         $ 40,000                         $ 40,000      
Work in process         998,000                         998,000      
Total $ 0       1,038,000                       $ 0 1,038,000     $ 1,038,000
Minimum supply period of raw materials that is not supported by firm, fixed orders and/or projections from collaborators considered to expense inventory                                 12 years        
Value of excess inventory 0                               $ 0        
Expense related to excess inventory $ 43,681,000 $ 47,243,000 $ 38,701,000 $ 44,831,000 $ 39,843,000 $ 31,689,000 $ 35,319,000 $ 32,888,000 $ 33,657,000 $ 32,909,000 $ 38,652,000 $ 36,094,000 $ 38,199,000 $ 35,132,000 $ 66,566,000 $ 73,331,000 $ 174,456,000 139,739,000 $ 141,312,000 $ 148,077,000  
Raw materials inventory write-downs                                   1,100,000      
Rolling period of firm, fixed orders for conjugate that the company is required to manufacture                                 6 months        
Rolling period of manufacturing projections for the quantity of conjugate the collaborator expects to need                                 12 months        
Maximum period of firm, fixed orders and/or projections from collaborators considered for capitalizing inventory                                 12 months        
Charges to research and development expense related to raw material inventory identified as excess                             $ 150,000   $ 0 $ 403,000   $ 1,100,000