CONSOLIDATED BALANCE SHEETS - USD ($)	Dec. 31, 2018	Dec. 31, 2017
ASSETS
Cash and cash equivalents	$ 262,252,000	$ 267,107,000
Accounts receivable	1,701,000	2,649,000
Unbilled revenue	617,000	2,580,000
Contract asset	500,000
Non-cash royalty receivable	9,249,000
Inventory	0	1,038,000
Prepaid and other current assets	4,462,000	2,967,000
Total current assets	278,781,000	276,341,000
Property and equipment, net of accumulated depreciation	12,891,000	14,538,000
Other assets	3,709,000	3,797,000
Total assets	295,381,000	294,676,000
LIABILITIES AND SHAREHOLDERS' EQUITY (DEFICIT)
Accounts payable	11,365,000	8,562,000
Accrued compensation	11,796,000	11,473,000
Other accrued liabilities	20,465,000	15,767,000
Current portion of deferred lease incentive	837,000	784,000
Current portion of liability related to the sale of future royalties, net of deferred financing costs of $753 and $772, respectively	25,880,000	17,779,000
Current portion of deferred revenue	317,000	1,405,000
Total current liabilities	70,660,000	55,770,000
Deferred lease incentive, net of current portion	4,675,000	5,129,000
Deferred revenue, net of current portion	80,485,000	93,752,000
Convertible 4.5% senior notes, net of deferred financing costs of $36 and $50, respectively	2,064,000	2,050,000
Liability related to the sale of future royalties, net of current portion and deferred financing costs of $1,536 and $2,373, respectively	122,345,000	151,634,000
Other long-term liabilities	4,180,000	4,236,000
Total liabilities	284,409,000	312,571,000
Commitments and contingencies (Note J)
Shareholders' deficit:
Preferred stock, $.01 par value; authorized 5,000 shares; no shares issued and outstanding
Common stock, $0.01 par value; authorized 200,000 shares; issued and outstanding 149,400 and 132,526 shares as of December 31, 2018 and December 31, 2017, respectively	1,494,000	1,325,000
Additional paid-in capital	1,192,813,000	1,009,362,000
Accumulated deficit	(1,183,335,000)	(1,028,582,000)
Total shareholders' equity (deficit)	10,972,000	(17,895,000)
Total liabilities and shareholders' equity (deficit)	$ 295,381,000	$ 294,676,000