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Agreements - Jazz Pharmaceuticals (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Aug. 31, 2017
USD ($)
product
item
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Dec. 31, 2017
USD ($)
Collaborative Agreements disclosures            
Remaining arrangement consideration to be recognized as license revenue   $ 80,592   $ 80,592   $ 93,752
Jazz Pharmaceuticals            
Collaborative Agreements disclosures            
Number of early stage ADC programs | item 2          
Number of ADC programs | item 3          
Payments received under collaboration agreement $ 75,000          
Term of agreement 7 years          
Number of products with rights to co-commercialize | product 1          
Offset to research and development expense   3,300 $ 1,300 7,100 $ 1,300  
Number of development and commercialization licenses | item 3          
Remaining arrangement consideration to be recognized as license revenue $ 75,000 $ 75,000   $ 75,000    
Jazz Pharmaceuticals | Maximum            
Collaborative Agreements disclosures            
Potential milestone payment $ 100,000