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Agreements - Fusion (Details)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Dec. 31, 2016
USD ($)
Mar. 31, 2015
item
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2018
USD ($)
item
Sep. 30, 2017
USD ($)
Dec. 31, 2017
USD ($)
May 31, 2018
USD ($)
Collaborative Agreements disclosures                
License and milestone fees     $ 672,000 $ 79,000 $ 13,533,000 $ 49,889,000    
Takeda                
Collaborative Agreements disclosures                
Term of agreement   3 years            
Number of single-target licenses | item   2     1      
License and milestone fees         $ 10,900,000      
Takeda | Phase 2 clinical trial                
Collaborative Agreements disclosures                
Potential milestone payment         $ 10,000,000      
Fusion Pharmaceuticals                
Collaborative Agreements disclosures                
Number of single-target licenses | item         1      
Potential milestone payment $ 50,000,000              
Fusion Pharmaceuticals | Development milestones                
Collaborative Agreements disclosures                
Potential milestone payment 15,000,000              
Fusion Pharmaceuticals | Phase 1 clinical trial                
Collaborative Agreements disclosures                
Contract asset recorded for the probable milestone 500,000              
Fusion Pharmaceuticals | Phase 2 clinical trial                
Collaborative Agreements disclosures                
Contract asset recorded for the probable milestone 1,500,000              
Fusion Pharmaceuticals | Sales milestones                
Collaborative Agreements disclosures                
Potential milestone payment $ 35,000,000              
ASU 2014-09 | Adjustments due to new guidance                
Collaborative Agreements disclosures                
Potential milestone payment     $ 500,000   $ 5,000,000      
ASU 2014-09 | Adjustments due to new guidance | Takeda | Phase 1 clinical trial                
Collaborative Agreements disclosures                
Contract asset recorded for the probable milestone               $ 5,000,000
Potential milestone payment             $ 5,000,000