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Agreements - Takeda (Details)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Mar. 31, 2015
item
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2018
USD ($)
item
Sep. 30, 2017
USD ($)
Dec. 31, 2017
USD ($)
May 31, 2018
USD ($)
Collaborative Agreements disclosures              
License and milestone fees   $ 672,000 $ 79,000 $ 13,533,000 $ 49,889,000    
Takeda              
Collaborative Agreements disclosures              
Term of agreement 3 years            
Number of single-target licenses | item 2     1      
License and milestone fees       $ 10,900,000      
Takeda | Phase 2 clinical trial              
Collaborative Agreements disclosures              
Potential milestone payment       10,000,000      
ASU 2014-09 | Adjustments due to new guidance              
Collaborative Agreements disclosures              
Potential milestone payment   $ 500,000   $ 5,000,000      
ASU 2014-09 | Adjustments due to new guidance | Takeda | Phase 1 clinical trial              
Collaborative Agreements disclosures              
Contract asset recorded for the probable milestone             $ 5,000,000
Potential milestone payment           $ 5,000,000