CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2018	Dec. 31, 2017
ASSETS
Cash and cash equivalents	$ 303,205	$ 267,107
Accounts receivable	2,115	2,649
Unbilled revenue	521	2,580
Contract asset	500
Non-cash royalty receivable	8,115
Inventory	1,938	1,038
Prepaid and other current assets	6,320	2,967
Total current assets	322,714	276,341
Property and equipment, net of accumulated depreciation	13,209	14,538
Other assets	3,941	3,797
Total assets	339,864	294,676
LIABILITIES AND SHAREHOLDERS? EQUITY (DEFICIT)
Accounts payable	10,352	8,562
Accrued compensation	10,316	11,473
Other accrued liabilities	24,117	15,767
Current portion of deferred lease incentive	832	784
Current portion of liability related to the sale of future royalties, net of deferred financing costs of $759 and $772, respectively	23,040	17,779
Current portion of deferred revenue	1,713	1,405
Total current liabilities	70,370	55,770
Deferred lease incentive, net of current portion	4,854	5,129
Deferred revenue, net of current portion	80,592	93,752
Convertible 4.5% senior notes, net of deferred financing costs of $40 and $50, respectively	2,060	2,050
Liability related to the sale of future royalties, net of current portion and deferred financing costs of $1,739 and $2,373, respectively	130,907	151,634
Other long-term liabilities	4,193	4,236
Total liabilities	292,976	312,571
Commitments and contingencies (Note I)
Shareholders' deficit:
Preferred stock, $.01 par value; authorized 5,000 shares; no shares issued and outstanding
Common stock, $0.01 par value; authorized 200,000 shares; issued and outstanding 149,049 and 132,526 shares as of September 30, 2018 and December 31, 2017, respectively	1,490	1,325
Additional paid-in capital	1,186,934	1,009,362
Accumulated deficit	(1,141,536)	(1,028,582)
Total shareholders? equity (deficit)	46,888	(17,895)
Total liabilities and shareholders? equity (deficit)	$ 339,864	$ 294,676