CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017
Cash flows from operating activities:
Net loss	$ (80,237)	$ (26,212)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(14,432)	(14,052)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	5,657	7,076
Depreciation and amortization	5,056	2,934
(Gain) loss on sale/disposal of fixed assets and impairment charges	(30)	180
Stock and deferred share unit compensation	7,872	5,801
Deferred rent	(59)	49
Change in operating assets and liabilities:
Accounts receivable	2,630	1,002
Unbilled revenue	2,058	4,971
Inventory	(852)	(1,290)
Prepaid and other current assets	(6,926)	628
Other assets	(640)	(128)
Accounts payable	3,871	(2,394)
Accrued compensation	(2,949)	266
Other accrued liabilities	1,896	802
Deferred revenue	(8,196)	11,487
Net cash used for operating activities	(85,281)	(8,880)
Cash flows from investing activities:
Purchases of property and equipment	(2,127)	(779)
Net cash used for investing activities	(2,127)	(779)
Cash flows from financing activities:
Proceeds from stock options exercised	2,819	32
Proceeds from common stock issuance, net of $367 of transaction costs	162,540
Net cash provided by financing activities	165,359	32
Net change in cash and cash equivalents	77,951	(9,627)
Cash and cash equivalents, beginning of period	267,107	159,964
Cash and cash equivalents, end of period	$ 345,058	$ 150,337