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Agreements - Jazz Pharmaceuticals (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Aug. 31, 2017
USD ($)
product
item
Jun. 30, 2018
USD ($)
Jun. 30, 2018
USD ($)
Dec. 31, 2017
USD ($)
Collaborative Agreements disclosures        
Remaining arrangement consideration to be recognized as license revenue   $ 80,751 $ 80,751 $ 93,752
Jazz Pharmaceuticals        
Collaborative Agreements disclosures        
Number of early stage ADC programs | item 2      
Number of ADC programs | item 3      
Payments received under collaboration agreement $ 75,000      
Term of agreement 7 years      
Number of products with rights to co-commercialize | product 1      
Offset to research and development expense   1,800 3,800  
Number of development and commercialization licenses | item 3      
Remaining arrangement consideration to be recognized as license revenue $ 75,000 $ 75,000 $ 75,000  
Jazz Pharmaceuticals | Maximum        
Collaborative Agreements disclosures        
Potential milestone payment $ 100,000