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Agreements - Takeda (Details)
$ in Thousands
1 Months Ended 6 Months Ended
May 31, 2018
USD ($)
Mar. 31, 2015
item
Jun. 30, 2018
USD ($)
item
Dec. 31, 2017
USD ($)
Collaborative Agreements disclosures        
Arrangement consideration included in long-term deferred revenue     $ 80,751 $ 93,752
Milestone recognized as contract asset     $ 4,041  
Takeda        
Collaborative Agreements disclosures        
Term of agreement   3 years    
Number of single-target licenses | item   2 1  
Arrangement consideration included in long-term deferred revenue     $ 10,900  
Takeda | Phase 1 clinical trial        
Collaborative Agreements disclosures        
Milestone recognized as contract asset $ 5,000      
Takeda | Phase 2 clinical trial        
Collaborative Agreements disclosures        
Potential milestone payment     $ 10,000