CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2018	Dec. 31, 2017
ASSETS
Cash and cash equivalents	$ 345,058	$ 267,107
Accounts receivable	19	2,649
Unbilled revenue	522	2,580
Non-cash royalty receivable	7,236
Inventory	1,890	1,038
Prepaid and other current assets	9,893	2,967
Total current assets	364,618	276,341
Property and equipment, net of accumulated depreciation	12,029	14,538
Other assets	4,437	3,797
Total assets	381,084	294,676
LIABILITIES AND SHAREHOLDERS’ EQUITY (DEFICIT)
Accounts payable	12,881	8,562
Accrued compensation	8,524	11,473
Other accrued liabilities	17,865	15,767
Current portion of deferred lease incentive	793	784
Current portion of liability related to the sale of future royalties, net of deferred financing costs of $788 and $772, respectively	22,265	17,779
Current portion of deferred revenue	1,020	1,405
Total current liabilities	63,348	55,770
Deferred lease incentive, net of current portion	4,806	5,129
Deferred revenue, net of current portion	80,751	93,752
Convertible 4.5% senior notes, net of deferred financing costs of $43 and $50, respectively	2,057	2,050
Liability related to the sale of future royalties, net of current portion and deferred financing costs of $1,918 and $2,373, respectively	136,701	151,634
Other long-term liabilities	4,231	4,236
Total liabilities	291,894	312,571
Commitments and contingencies (Note I)
Shareholders' deficit:
Preferred stock, $.01 par value; authorized 5,000 shares; no shares issued and outstanding
Common stock, $0.01 par value; authorized 200,000 shares; issued and outstanding 149,021 and 132,526 shares as of June 30, 2018 and December 31, 2017, respectively	1,490	1,325
Additional paid-in capital	1,182,429	1,009,362
Accumulated deficit	(1,094,729)	(1,028,582)
Total shareholders’ equity (deficit)	89,190	(17,895)
Total liabilities and shareholders’ equity (deficit)	$ 381,084	$ 294,676