CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Cash flows from operating activities:
Net loss	$ (38,613)	$ (17,345)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(7,190)	(7,613)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	3,046	3,575
Depreciation and amortization	2,527	1,506
(Gain) loss on sale/disposal of fixed assets and impairment charges	(30)	180
Stock and deferred share unit compensation	3,847	2,665
Deferred rent	15	25
Change in operating assets and liabilities:
Accounts receivable	2,615	(1,867)
Unbilled revenue	(258)	4,727
Inventory	670	(1,033)
Prepaid and other current assets	(2,713)	(1,008)
Other assets	(884)	(173)
Accounts payable	(757)	(2,543)
Accrued compensation	(5,802)	(2,019)
Other accrued liabilities	5,447	775
Deferred revenue	(11,875)	(12,811)
Net cash used for operating activities	(49,955)	(32,959)
Cash flows from investing activities:
Purchases of property and equipment	(1,028)	(437)
Net cash used for investing activities	(1,028)	(437)
Cash flows from financing activities:
Proceeds from stock options exercised	2,259
Net cash provided by financing activities	2,259
Net change in cash and cash equivalents	(48,724)	(33,396)
Cash and cash equivalents, beginning of period	267,107	159,964
Cash and cash equivalents, end of period	$ 218,383	$ 126,568