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Agreements - Debiopharm (Details) - USD ($)
1 Months Ended 3 Months Ended
May 24, 2017
Jan. 31, 2018
Mar. 31, 2018
Dec. 31, 2017
Mar. 31, 2017
May 24, 2016
Collaborative Agreements disclosures            
License and milestone fees     $ 11,540,000   $ 18,730,000  
Research and development support     383,000   $ 1,478,000  
Debiopharm            
Collaborative Agreements disclosures            
Payments received under collaboration agreement $ 25,000,000          
Potential milestone payments 5,000,000 $ 4,500,000 $ 0 $ 5,000,000    
Fair value of consideration for services provided 30,000,000          
License and milestone fees 29,700,000 $ 500,000   $ 29,500,000    
Research and development support $ 300,000          
Debiopharm | Phase 3 Clinical Trial            
Collaborative Agreements disclosures            
Potential milestone payments           $ 25,000,000