CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
ASSETS
Cash and cash equivalents	$ 218,383	$ 267,107
Accounts receivable	34	2,649
Unbilled revenue	2,838	2,580
Contract asset	4,041
Non-cash royalty receivable	16,090
Inventory	368	1,038
Prepaid and other current assets	5,680	2,967
Total current assets	247,434	276,341
Property and equipment, net of accumulated depreciation	12,850	14,538
Other assets	4,681	3,797
Total assets	264,965	294,676
LIABILITIES AND SHAREHOLDERS' DEFICIT
Accounts payable	7,786	8,562
Accrued compensation	5,671	11,473
Other accrued liabilities	23,756	15,767
Current portion of deferred lease incentive	784	784
Current portion of liability related to the sale of future royalties, net of deferred financing costs of $828 and $772, respectively	27,619	17,779
Current portion of deferred revenue	611	1,405
Total current liabilities	66,227	55,770
Deferred lease incentive, net of current portion	4,933	5,129
Deferred revenue, net of current portion	81,522	93,752
Convertible 4.5% senior notes, net of deferred financing costs of $47 and $50, respectively	2,053	2,050
Liability related to the sale of future royalties, net of current portion and deferred financing costs of $2,092 and $2,373, respectively	142,018	151,634
Other long-term liabilities	4,523	4,236
Total liabilities	301,276	312,571
Commitments and contingencies (Note I)
Shareholders' deficit:
Preferred stock, $.01 par value; authorized 5,000 shares; no shares issued and outstanding
Common stock, $0.01 par value; authorized 200,000 shares; issued and outstanding 133,024 and 132,526 shares as of March 31, 2018 and December 31, 2017, respectively	1,330	1,325
Additional paid-in capital	1,015,464	1,009,362
Accumulated deficit	(1,053,105)	(1,028,582)
Total shareholders’ deficit	(36,311)	(17,895)
Total liabilities and shareholders’ deficit	$ 264,965	$ 294,676