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Agreements - Jazz (Details)
$ in Millions
1 Months Ended 12 Months Ended
Aug. 31, 2017
USD ($)
product
item
Dec. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Collaborative Agreements disclosures      
Remaining arrangement consideration to be recognized as license revenue   $ 6.8 $ 7.1
Jazz      
Collaborative Agreements disclosures      
Number of early stage ADC programs | item 2    
Number of ADC programs | item 3    
Number of products with rights to co-commercialize | product 1    
Number of products with rights under certain limited circumstances | product 2    
Payments received under collaboration agreement $ 75.0    
Potential milestone payments $ 100.0    
Term of agreement 7 years    
Offset to research and development expense   3.3  
Number of development and commercialization licenses | item 3    
Discount rate (as a percent) 14.00%    
Estimated utilization period after commercialization 10 years    
Remaining arrangement consideration to be recognized as license revenue   $ 75.0