CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
ASSETS
Cash and cash equivalents	$ 267,107	$ 159,964
Accounts receivable	2,649	2,026
Unbilled revenue	2,580	6,778
Inventory	1,038	2,192
Prepaid and other current assets	2,967	5,386
Total current assets	276,341	176,346
Property and equipment, net of accumulated depreciation	14,538	19,498
Other assets	3,797	3,020
Total assets	294,676	198,864
LIABILITIES AND SHAREHOLDERS' DEFICIT
Accounts payable	8,562	7,895
Accrued compensation	11,473	6,946
Other accrued liabilities	15,767	11,150
Current portion of deferred lease incentive	784	784
Current portion of liability related to the sale of future royalties, net of deferred financing costs of $772 and $850, respectively	17,779	14,470
Current portion of deferred revenue	1,405	14,531
Total current liabilities	55,770	55,776
Deferred lease incentive, net of current portion	5,129	5,914
Deferred revenue, net of current portion	93,752	19,086
Convertible 4.5% senior notes, net of deferred financing costs of $50 and $3,035, respectively	2,050	96,965
Liability related to the sale of future royalties, net of current portion and deferred financing costs of $2,373 and $3,144, respectively	151,634	169,858
Other long-term liabilities	4,236	4,115
Total liabilities	312,571	351,714
Commitments and contingencies (Note H)
Shareholders' deficit:
Preferred stock, $.01 par value; authorized 5,000 shares; no shares issued and outstanding
Common stock, $0.01 par value; authorized 200,000 shares; issued and outstanding 132,526 and 87,301 shares as of December 31, 2017 and December 31, 2016, respectively	1,325	873
Additional paid-in capital	1,009,362	778,847
Accumulated deficit	(1,028,582)	(932,570)
Total shareholders’ deficit	(17,895)	(152,850)
Total liabilities and shareholders’ deficit	$ 294,676	$ 198,864