CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016
Cash flows from operating activities:
Net loss	$ (82,894)	$ (122,581)
Adjustments to reconcile net loss to net cash used for operating activities:
Non-cash royalty revenue related to sale of future royalties	(20,555)	(19,508)
Non-cash interest expense on liability related to sale of future royalties and convertible senior notes	10,461	14,946
Non-cash debt conversion expense	22,191
Depreciation and amortization	4,307	4,468
Loss on sale/disposal of fixed assets and impairment charges	180	975
Stock and deferred share unit compensation	8,458	16,359
Deferred rent	71	168
Change in operating assets and liabilities:
Accounts receivable	(495)	487
Unbilled revenue	4,178	(575)
Inventory	(51)	(490)
Prepaid and other current assets	641	(863)
Other assets	(93)	(195)
Accounts payable	(993)	(2,645)
Accrued compensation	1,579	1,291
Other accrued liabilities	2,781	1,938
Deferred revenue	87,288	(790)
Proceeds from landlord for tenant improvements		185
Net cash provided (used) for operating activities	37,054	(106,830)
Cash flows from investing activities:
Purchases of property and equipment	(847)	(6,431)
Net cash used for investing activities	(847)	(6,431)
Cash flows from financing activities:
Proceeds from stock options exercised	363	370
Fees for debt conversion	(1,683)
Proceeds from issuance of convertible 4.5% notes, net of $3,392 of transaction costs		96,608
Net cash (used) provided by financing activities	(1,320)	96,978
Net change in cash and cash equivalents	34,887	(16,283)
Cash and cash equivalents, beginning balance	159,964	212,283
Cash and cash equivalents, ending balance	$ 194,851	$ 196,000